Allergic-type reactions to corticosteroids

The word essential is sometimes synonymous with idiopathic (as in essential proteinuria or essential thrombocythemia ), and the same is true of primary (as in primary biliary cirrhosis or primary amenorrhea ), with the latter term being used in such cases to contrast with secondary in the sense of "secondary to [ . , caused by] some other condition." Another, less common synonym is agnogenic ( agno- , "unknown" + -gen , "cause" + -ic ). The word cryptogenic ( crypto- , "hidden" + -gen , "cause" + -ic ) has a sense that is synonymous with idiopathic [4] and a sense that is contradistinguished from it.

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S25627   02/17

The gastric acid suppression during treatment with esomeprazole, and other PPIs might decrease or increase the absorption of drugs with a gastric pH dependent absorption. Like with other drugs that decrease the intragastric acidity, the absorption of drugs such as ketoconazole, itraconazole, posaconazole and erlotinib can decrease while the absorption of drugs such as digoxin can increase during treatment with esomeprazole. Concomitant use with posaconazole and erlotinib should be avoided. Concomitant treatment with omeprazole (20 mg daily) and digoxin in healthy subjects increased the bioavailability of digoxin by 10% (up to 30% in two out of ten subjects).

Dopaminergic agonists, in clinical studies and clinical experience, appear to impair the systemic regulation of blood pressure , resulting in postural/orthostatic hypotension, especially during dose escalation. Parkinson's disease patients, in addition, appear to have an impaired capacity to respond to a postural challenge. For these reasons, both Parkinson's and RLS patients being treated with dopaminergic agonists ordinarily (1) require careful monitoring for signs and symptoms of postural hypotension, especially during dose escalation, and (2) should be informed of this risk.

Allergic-type reactions to corticosteroids

allergic-type reactions to corticosteroids

Dopaminergic agonists, in clinical studies and clinical experience, appear to impair the systemic regulation of blood pressure , resulting in postural/orthostatic hypotension, especially during dose escalation. Parkinson's disease patients, in addition, appear to have an impaired capacity to respond to a postural challenge. For these reasons, both Parkinson's and RLS patients being treated with dopaminergic agonists ordinarily (1) require careful monitoring for signs and symptoms of postural hypotension, especially during dose escalation, and (2) should be informed of this risk.

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