Whether airway hyperresponsiveness is a symptom of airway inflammation or airway remodeling, or whether it is the cause of long-term loss of lung function, remains controversial. Some investigators have hypothesized that aggressive treatment with anti-inflammatory therapies improves the long-term course of asthma beyond their salutary effects on parameters of asthma control and rates of exacerbation over time. 13 This contention has been supported by an observational study 14 that found long-term exposure to ICS was associated with an attenuation of the accelerated decline in lung function previously reported in asthmatics; more studies are required to substantiate these findings.
Salbutamol has been shown to improve muscle weight in rats  and anecdotal reports hypothesise that it might be an alternative to clenbuterol for purposes of fat burning and muscle gain, with multiple studies supporting this claim.     Abuse of the drug may be confirmed by detection of its presence in plasma or urine, typically exceeding 1000 µg/L. The window of detection for urine testing is on the order of just 24 hours, given the relatively short elimination half-life of the drug,    estimated at between 5 and 6 hours following oral administration of 4 mg.