Acamprosate is available in 333-mg enteric, coated tablets; dosing is by weight ( Table 1 3 , 4 ). It is well tolerated with limited side effects, most commonly transient diarrhea (occurring in approximately 10 percent of patients). There are no interactions with concomitant use of alcohol, diazepam (Valium), disulfiram, or imipramine (Tofranil), so patients with alcohol dependence can continue to use acamprosate during a relapse. Patients with renal insufficiency or advanced cirrhosis should not take acamprosate, but it may be taken safely by patients with liver dysfunction. 11 Like naltrexone and disulfiram, acamprosate is FDA pregnancy category C (adverse effects on the fetus in animal studies but no human trials).