The following adverse reactions have been observed during appropriate use of somatropin: headaches (children and adults), gynecomastia (children), and pancreatitis (children and adults). In studies of growth hormone-deficient children, injection-site reactions (., pain, bruise) occurred in 8 of the 164 treated patients. Leukemia and new-onset type 2 diabetes mellitus have been reported. Serious systemic hypersensitivity reactions including anaphylactic reactions and angioedema have been reported with postmarketing use of somatropin products.
Adrenal gland function, as well as the synthesis of cortisol, is dependent on an adequate supply of various vitamins. Vitamin C levels are among the highest in the adrenal glands compared with other organs. Vitamin C plays a major role in neurotransmitter production and supports general health of the adrenals. Under stressful conditions, vitamin C and B complex vitamins are readily used and excreted from the body. Within the B vitamin family, pantothenic acid breaks down into coenzyme A, which is essential for the production of energy from ingested carbohydrates, fats and proteins. In a study evaluating the effects of pantothenic acid and glutathione production, pantothenic acid was found to increase CoA levels in the body, leading to increased energy production. Niacin also plays a vital role in many metabolic functions in the body, including supplying energy to cells and assisting in the production of adrenal hormones.
Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and hence may explain why aspirin improves glycemic control in type 2 diabetes.  Epigallocatechin gallate from green tea can also potently inhibit this enzyme,  green tea is a complex mixture of various phenolics with contents varying with production and processing, some of the phenolics are known HDAC inhibitors that alter genetic expression. EGCG as usually consumed in green tea is poorly absorbed into the bloodstream, more research is needed to reach firm conclusions.