Is cholesterol synthesis from acetyl-coa molecules an anabolic reaction

The conversion of HMG-CoA to mevalonate by HMG-CoA reductase is the rate-limiting step of cholesterol biosynthesis and is under strict regulatory control (see Figure 1 ). HMGR is the target of compounds that are effective in lowering serum cholesterol levels. Human HMG-CoA reductase consists of a single polypeptide chain of 888 amino acids. The amino-terminal residues are membrane bound and reside in the endoplasmic reticulum membrane, while the catalytic site of the protein resides in its cytoplasmic, soluble carboxy-terminal portion. A linker region connects the two portions of the protein.

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10. Cannel, MD, John Jacob, "The Truth About Vitamin D Toxicity," http:///. Published September 4, 2003. Accessed May 24, 2006. 11. Rosenfeld, Louis, "Vitamine - vitamin. The early years of discovery," Clinical Chemistry, Vol. 43 No. 4 (1997) 680-685. 12. DeLuca, Hector F., "Historical Overview," in Feldman et al., eds., Vitamin D, San Diego: Academic Press (1997) 3-11. 13. Dobs, et al., "Effects of pravastatin, a new HMG-CoA reductase inhibitor, on vitamin D synthesis in man," Metabolism, Vol. 40 No. 5 (1991) 524-8. 14. Folkers, et al., "Lovastatin decreases coenzyme Q levels in humans," Proc Natl Acad Sci USA Vol. 87 No. 22 (1990) 8931-4. 15. Heaney, Robert P., "The Vitamin D requirement in health and disease," Journal of Steroid Biochemistry & Molecular Biology, 97 (2005)13-19. 16. Cannel, MD, John Jacob, "The Vitamin D Newsletter: April 2006 -- Dr. Cannell Answers Readers' Questions," Vitamin D Council: http:///PDFs/April2006-. Published April 1, 2006. Accessed May 25, 2006. 17. Masterjohn, Chris, "Vitamin A on Trial: Does Vitamin A Cause Osteoporosis?" Wise Traditions , Spring 2006.

Is cholesterol synthesis from acetyl-coa molecules an anabolic reaction

is cholesterol synthesis from acetyl-coa molecules an anabolic reaction

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