I dress for the environment when walking to work because I'm constantly being sized up and interviewed by the predators that loiter around and if I didn't I'd eventually be viewed as an outsider and ripe for the pickings. Now I should state that I'm actually quite intimating at over 6 foot and currently about 220 pounds so i don't have a lot of people challenging me. But if I was challenged I can handle myself because after 30 years of martial arts training and teaching and having spent over 4 years training and fighting in Thailand, I'm fairly confident that if it came to blows I'd come away okay. Guns and knives are another story.
The secretion of hypothalamic, pituitary, and target tissue hormones is under tight regulatory control by a series of feedback and feed- forward loops. This complexity can be demonstrated using the growth hormone (GH) regulatory system as an example. The stimulatory substance growth hormone releasing hormone (GHRH) and the inhibitory substance somatostatin (SS) both products of the hypothalamus, control pituitary GH secretion. Somatostatin is also called growth hormone-inhibiting hormone (GHIH). Under the influence of GHRH, growth hormone is released into the systemic circulation, causing the target tissue to secrete insulin-like growth factor-1, IGF-1. Growth hormone also has other more direct metabolic effects; it is both hyperglycemic and lipolytic. The principal source of systemic IGF-1 is the liver, although most other tissues secrete and contribute to systemic IGF-1. Liver IGF-1 is considered to be the principal regulator of tissue growth. In particular, the IGF-1 secreted by the liver is believed to synchronize growth throughout the body, resulting in a homeostatic balance of tissue size and mass. IGF-1 secreted by peripheral tissues is generally considered to be autocrine or paracrine in its biological action.