No matter what you're looking for — learning or fun — has it! Free online puzzles. Cool math games. Number games. (More addictive than Sudoku or Kakuro? You decide!) Educational games for kids. Visit our For Teachers section for math teacher resources, our free KenKen Classroom program, and a message from Tetsuya Miyamoto, the Japanese educator behind KenKen. Miyamoto, chess master David Levy, and the rest of Team KenKen have crafted these math puzzles into great games for learning and brain training. Need even more KenKen? Check out our Will Shortz Presents books. Try our mobile app on iPhone and iPad or our Kindle version. Play on the New York Times puzzle page and NCTM website. Regardless of why, how, or where you play, KenKen are the math puzzles that make you smarter!
Several weeks of exogenous glucocorticoid therapy are typically required for development of adrenal insufficiency (Salvatori, 2005; Chrousos, 2015). Longer-acting glucocorticoids, and higher doses of systemic glucocorticoids (vs topical or inhaled formulations) have been associated with a higher risk of developing adrenal suppression. There are no current evidence-based guidelines regarding the optimal method for discontinuing glucocorticoid therapy, although gradual tapering of dosages over a period of weeks to months, prior to complete discontinuation, is recommended to allow time for recovery of the hypothalamic-pituitary-adrenal axis (Liu et al, 2013).