Among those who headlined an event but were not tested by USADA: featherweight Charles Oliveira, who headlined UFC Fight Night 74 opposite Max Holloway; Glover Teixeira and Ovince Saint Preux, who headlined UFC Fight Night 73; bantamweight champ . Dillashaw and ex-champ Renan Barao, who headlined UFC on FOX 16; Michael Bisping and Thales Leites, who headlined UFC Fight Night 72; and Jake Ellenberger and Stephen Thompson, who headlined The Ultimate Fighter 21 Finale. It is unknown whether the fighters were tested by state-run athletic commissions.
The first bout on the televised portion of the event saw Nate Diaz taking on Clay Guida in a lightweight contest. Diaz, who had an eight-inch reach advantage on Guida, was able to frustrate him with punches on the feet while Guida has success with leg-kicks followed by a right hand straight.  After closing the distance, Guida used his wrestling experience to avoid submissions while controlling and pressuring Diaz both in the clinch and on the ground throughout the fight. Diaz rallied with punches in the final round but was unable to finish off Guida. The judges scored the bout 29–28 twice for Guida and once for Diaz for the split-decision victory.  The bout was awarded the event's second "Fight of the Night" honor gaining both fighters a $65,000 bonus.